Decision tool and Sample Size Calculator for Composite Endpoints

10 Jan 2020 Roig Marta Bofill Martínez Jordi Cortés Melis Guadalupe Gómez

Summary points: - This article considers the combination of two binary or two time-to-event endpoints to form the primary composite endpoint for leading a trial. - It discusses the relative efficiency of choosing a composite endpoint over one of its components in terms of: the frequencies of observing each component; the relative treatment effect of the tested therapy; and the association between both components... (read more)

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