Estimation of the number of spikes using a generalized spike population model and application to RNA-seq data

27 Apr 2018 Choi Hyo Young Marron J. S.

Although a generalized spike population model has been actively studied in random matrix theory, its application to real data has been rarely explored. We find that most methods for determining the number of spikes based on the Johnstone's spike population model choose far too many spikes in RNA-seq gene expression data or often fail to determine the number of spikes by indicating that all components are spikes... (read more)

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  • METHODOLOGY