Supervised variable selection in randomised controlled trials prior to exploration of treatment effect heterogeneity: an example from severe malaria

11 Jan 2019 Wu Chieh-Hsi Holmes Chris C.

Exploration of treatment effect heterogeneity (TEH) is an increasingly important aspect of modern statistical analysis for stratified medicine in randomised controlled trials (RCTs) as we start to gather more information on trial participants and wish to maximise the opportunities for learning from data. However, the analyst should refrain from including a large number of variables in a treatment interaction discovery stage... (read more)

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